{"id":1411225,"date":"2025-06-17T10:19:20","date_gmt":"2025-06-17T08:19:20","guid":{"rendered":"https:\/\/dnaera.com\/ro\/?p=1411225"},"modified":"2025-06-17T10:19:23","modified_gmt":"2025-06-17T08:19:23","slug":"citalopram-liecba-sita-na-mieru-podla-vasej-dna","status":"publish","type":"post","link":"https:\/\/dnaera.com\/ro\/blog\/citalopram-liecba-sita-na-mieru-podla-vasej-dna\/","title":{"rendered":"Citalopram: Lie\u010dba \u0161it\u00e1 na mieru pod\u013ea va\u0161ej DNA"},"content":{"rendered":"\n<p><p>Du\u0161evn\u00e9 poruchy m\u00f4\u017eu ma\u0165 mnoho pod\u00f4b \u2013 od pretrv\u00e1vaj\u00faceho sm\u00fatku a\u017e po siln\u00fa \u00fazkos\u0165, ktor\u00e1 ochromuje be\u017en\u00e9 fungovanie. V takej chv\u00edli m\u00f4\u017ee pr\u00eds\u0165 na rad <b>citalopram<\/b> \u2013 lie\u010divo, ktor\u00e9 s\u00edce nie je z\u00e1zra\u010dn\u00fdm rie\u0161en\u00edm, ale predstavuje d\u00f4le\u017eit\u00fd n\u00e1stroj na stabiliz\u00e1ciu psychick\u00e9ho stavu a vytvorenie priestoru pre \u010fal\u0161ie formy podpory, napr\u00edklad psychoterapiu. \u00da\u010dinnos\u0165 tohto lie\u010diva sa v\u0161ak m\u00f4\u017ee v\u00fdrazne l\u00ed\u0161i\u0165 v z\u00e1vislosti od genetickej vari\u00e1cie v jednom konkr\u00e9tnom g\u00e9ne \u2013 <b>CYP2C19<\/b>.<\/p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong><strong>\u010co je Citalopram a ako p\u00f4sob\u00ed?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>Citalopram patr\u00ed medzi antidepres\u00edva typu SSRI \u2013 selekt\u00edvne inhib\u00edtory sp\u00e4tn\u00e9ho vychyt\u00e1vania seroton\u00ednu. V preklade: pom\u00e1ha zv\u00fd\u0161i\u0165 hladinu seroton\u00ednu, teda \u201ehorm\u00f3nu dobrej n\u00e1lady\u201c, v mozgu. Seroton\u00edn je zodpovedn\u00fd za to, ako sa c\u00edtime, ako sp\u00edme \u010di ako zn\u00e1\u0161ame stres.<\/p>\n\n\n\n<p>Tento liek sa predpisuje nielen pri depresii, ale aj pri \u00fazkostn\u00fdch poruch\u00e1ch, panick\u00fdch atakoch, posttraumatickej stresovej poruche \u010di dokonca pri obses\u00edvno-kompulz\u00edvnej poruche.<\/p>\n\n\n<p><!-- \/wp:post-content --><!-- wp:heading --><\/p>\n<h2><strong><strong><strong><strong><strong><strong><strong><strong><strong>Ke\u010f sa lie\u010dba stretne s genetikou<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p>Predstavte si troch \u013eud\u00ed, rovnak\u00fd vek, rovnak\u00e1 diagn\u00f3za, rovnak\u00e9 lie\u010divo. Prv\u00fd po mesiaci c\u00edti \u00fa\u013eavu, druh\u00fd len nepr\u00edjemn\u00e9 ved\u013eaj\u0161ie \u00fa\u010dinky a\u00a0tret\u00ed sa c\u00edti, akoby ni\u010d neu\u017e\u00edval. Ako je to mo\u017en\u00e9?<\/p>\n<p>Ide o\u00a0odli\u0161n\u00fd metabolizmus lie\u010diva, v ktorom zohr\u00e1va rolu na\u0161a genetika. Po u\u017eit\u00ed sa citalopram sprac\u00fava v pe\u010deni pomocou enz\u00fdmov, pri\u010dom k\u013e\u00fa\u010dov\u00fdm hr\u00e1\u010dom je enz\u00fdm CYP2C19. Tento enz\u00fdm v\u0161ak nefunguje rovnako u ka\u017ed\u00e9ho.<\/p>\n<p><b>Pozn\u00e1me p\u00e4\u0165 z\u00e1kladn\u00fdch typov metaboliz\u00e9rov:<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400\">ultrar\u00fdchly metaboliz\u00e9r \u2013 lie\u010divo sa rozklad\u00e1 ve\u013emi r\u00fdchlo, \u00fa\u010dinok m\u00f4\u017ee by\u0165 slab\u00fd alebo \u017eiadny,<\/li>\n<li style=\"font-weight: 400\">r\u00fdchly metaboliz\u00e9r \u2013 lie\u010divo sa rozklad\u00e1 r\u00fdchlej\u0161ie ako u\u00a0\u0161tandardn\u00e9ho metaboliz\u00e9ra, ale st\u00e1le \u00fa\u010dinne,<\/li>\n<li style=\"font-weight: 400\">\u0161tandardn\u00fd metaboliz\u00e9r \u2013 ide\u00e1lna rovnov\u00e1ha medzi \u00fa\u010dinnos\u0165ou a bezpe\u010dnos\u0165ou,<\/li>\n<li style=\"font-weight: 400\">slab\u0161\u00ed metaboliz\u00e9r \u2013 pomal\u0161ie odb\u00faravanie lie\u010diva, zv\u00fd\u0161en\u00e9 riziko ved\u013eaj\u0161\u00edch \u00fa\u010dinkov,<\/li>\n<li style=\"font-weight: 400\">slab\u00fd metaboliz\u00e9r \u2013 pomal\u00e9 odb\u00faravanie lie\u010diva.<\/li>\n<\/ul>\n<p>To znamen\u00e1, \u017ee genetick\u00e1 variabilita v g\u00e9ne <b>CYP2C19<\/b> rozhoduje o tom, ak\u00fd efekt na n\u00e1s bude ma\u0165 u\u017e\u00edvanie citalopramu. Pr\u00edli\u0161 ve\u013ea lie\u010diva v tele m\u00f4\u017ee vies\u0165 k poruch\u00e1m srdcov\u00e9ho rytmu (napr. pred\u013a\u017eenie QT intervalu), pr\u00edli\u0161 m\u00e1lo zas k nulov\u00e9mu efektu.<\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading --><\/p>\n<h2><strong>Ak\u00e1 je v\u00fdhoda poznania tejto genetickej predispoz\u00edcie?<\/strong><\/h2>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p>Lie\u010dba du\u0161evn\u00fdch por\u00fach nie je jednoduch\u00e1, no ani bezn\u00e1dejn\u00e1. Vy\u017eaduje trpezlivos\u0165, odbornos\u0165 a predov\u0161etk\u00fdm individu\u00e1lny pr\u00edstup. Nie ka\u017ed\u00fd liek zaberie rovnako u ka\u017ed\u00e9ho pacienta. Poznanie genetickej predispoz\u00edcie pre metabolizmus citalopramu je d\u00f4le\u017eitou inform\u00e1ciou, ktor\u00e1 lek\u00e1rovi umo\u017en\u00ed lep\u0161ie a r\u00fdchlej\u0161ie optimalizova\u0165 u\u017e\u00edvanie tohto lie\u010diva a v pr\u00edpade potreby odporu\u010di\u0165 in\u00e9 mo\u017enosti lie\u010dby.<\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading --><\/p>\n<h2><strong><strong><strong><strong><strong><strong><strong><strong>Nov\u00fd v\u00fdsledok anal\u00fdzy<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><a href=\"https:\/\/app.dnaera.com\/ro\/sign-in\">Prihl\u00e1ste sa do svojich v\u00fdsledkov.<\/a> Nov\u00e1 predispoz\u00edcia je odteraz zadarmo dostupn\u00e1 pre v\u0161etk\u00fdch na\u0161ich s\u00fa\u010dasn\u00fdch z\u00e1kazn\u00edkov. Z\u00e1rove\u0148 ju bude ma\u0165 vo svojej anal\u00fdze ka\u017ed\u00fd bud\u00faci z\u00e1kazn\u00edk, ktor\u00fd vst\u00fapi do sveta DNA s <a href=\"https:\/\/dnaera.com\/ro\/produkt\/dna-complex-test\/\">DNA Complex testom<\/a> alebo<a href=\"https:\/\/dnaera.com\/ro\/produkt\/dna-health-test\/\"> DNA Health testom<\/a>.\u00a0Pozna\u0165 svoje g\u00e9ny m\u00e1 zmysel v ka\u017edom veku. \u010c\u00edm sk\u00f4r, t\u00fdm lep\u0161ie. Za\u010dnite objavova\u0165 svoju DNA aj vy.<\/p>\n<p><!-- \/wp:paragraph --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n\n<!-- wp:paragraph -->\n<p>Zdroje:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list {\"ordered\":true} -->\n<ol class=\"wp-block-list\"><!-- wp:list-item {\"fontSize\":\"small\"} -->\n<li class=\"has-small-font-size\">Bousman, C. A., Stevenson, J. M., Ramsey, L. B., Sangkuhl, K., Hicks, J. K., Strawn, J. R., &#8230; &amp; Bishop, J. R. (2023). Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants. Clinical Pharmacology &amp; Therapeutics, 114(1), 51-68.<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item {\"fontSize\":\"small\"} -->\n<li class=\"has-small-font-size\">Milne, R. J., &amp; Goa, K. L. (1991). Citalopram: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs, 41, 450-477.<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item {\"fontSize\":\"small\"} -->\n<li class=\"has-small-font-size\">Masand, P. S., &amp; Gupta, S. (1999). Selective serotonin-reuptake inhibitors: an update. Harvard review of psychiatry, 7(2), 69-84.<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item {\"fontSize\":\"small\"} -->\n<li class=\"has-small-font-size\"><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a699001.html\">https:\/\/medlineplus.gov\/druginfo\/meds\/a699001.html<\/a><\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item {\"fontSize\":\"small\"} -->\n<li class=\"has-small-font-size\"><a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/22572-serotonin\">https:\/\/my.clevelandclinic.org\/health\/articles\/22572-serotonin<\/a><\/li>\n<!-- \/wp:list-item --><\/ol>\n<!-- \/wp:list -->","protected":false},"excerpt":{"rendered":"<p>Du\u0161evn\u00e9 poruchy m\u00f4\u017eu ma\u0165 mnoho pod\u00f4b \u2013 od pretrv\u00e1vaj\u00faceho sm\u00fatku a\u017e po siln\u00fa \u00fazkos\u0165, ktor\u00e1 ochromuje be\u017en\u00e9 fungovanie. V takej chv\u00edli m\u00f4\u017ee pr\u00eds\u0165 na rad citalopram \u2013 lie\u010divo, ktor\u00e9 s\u00edce nie je z\u00e1zra\u010dn\u00fdm rie\u0161en\u00edm, ale predstavuje d\u00f4le\u017eit\u00fd n\u00e1stroj na stabiliz\u00e1ciu psychick\u00e9ho stavu a vytvorenie priestoru pre \u010fal\u0161ie formy podpory, napr\u00edklad psychoterapiu. \u00da\u010dinnos\u0165 tohto lie\u010diva sa [&hellip;]<\/p>\n","protected":false},"author":876,"featured_media":1411226,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":"[]"},"categories":[1],"tags":[58,59,111,30],"place-taxonomy":[47],"class_list":["post-1411225","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sk","tag-dna-analyza","tag-dna-test","tag-predispozicia","tag-zdravie"],"acf":[],"views":6065,"_links":{"self":[{"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/posts\/1411225","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/users\/876"}],"replies":[{"embeddable":true,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/comments?post=1411225"}],"version-history":[{"count":5,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/posts\/1411225\/revisions"}],"predecessor-version":[{"id":1411234,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/posts\/1411225\/revisions\/1411234"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/media\/1411226"}],"wp:attachment":[{"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/media?parent=1411225"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/categories?post=1411225"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/tags?post=1411225"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dnaera.com\/ro\/wp-json\/wp\/v2\/place-taxonomy?post=1411225"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}