{"id":1374788,"date":"2023-03-14T12:10:46","date_gmt":"2023-03-14T11:10:46","guid":{"rendered":"https:\/\/dnaera.com\/hu\/?p=1374788"},"modified":"2023-04-17T09:21:42","modified_gmt":"2023-04-17T07:21:42","slug":"mutyh","status":"publish","type":"post","link":"https:\/\/dnaera.com\/hu\/blog\/mutyh\/","title":{"rendered":"Aj vznik polypov ved\u00facich k n\u00e1dorom ovplyv\u0148uj\u00fa g\u00e9ny"},"content":{"rendered":"\n

Na\u0161i z\u00e1kazn\u00edci si vo svojich v\u00fdsledkoch n\u00e1jdu nov\u00fa predispoz\u00edciu spojen\u00fa s genetick\u00fdm ochoren\u00edm zaraden\u00fdm v kateg\u00f3rii Status pren\u00e1\u0161a\u010da. MUTYH asociovan\u00e1 polyp\u00f3za, v skratke MAP, je geneticky podmienen\u00e9 ochorenie prejavuj\u00face sa a\u017e v dospelosti. Z v\u00fdsledku anal\u00fdzy DNA m\u00f4\u017eete zisti\u0165 \u010di ste pren\u00e1\u0161a\u010dom ochorenia, ale aj \u010di m\u00e1te vy\u0161\u0161ie riziko vy sami. A pr\u00e1ve preto je ve\u013ekou v\u00fdhodou pozna\u0165 svoju predispoz\u00edciu e\u0161te pred prv\u00fdmi pr\u00edznakmi. <\/em><\/p>\n\n\n\n

D\u00f4le\u017eitos\u0165 prevencie kolorekt\u00e1lneho karcin\u00f3mu<\/h2>\n\n\n\n

Karcin\u00f3m \u010dreva a kone\u010dn\u00edka (kolorekt\u00e1lny karcin\u00f3m) predstavuje v na\u0161ich kon\u010din\u00e1ch jedno z naj\u010dastej\u0161\u00edch onkologick\u00fdch ochoren\u00ed. Pri rozvoji n\u00e1doru zohr\u00e1vaj\u00fa d\u00f4le\u017eit\u00fa \u00falohu zmeny v DNA. K t\u00fdmto zmen\u00e1m m\u00f4\u017ee doch\u00e1dza\u0165 aj \u00faplne n\u00e1hodou, a preto je pre v\u010dasn\u00e9 odhalenie n\u00e1doru k\u013e\u00fa\u010dov\u00e1 sekund\u00e1rna prevencia v podobe prevent\u00edvnych prehliadok u lek\u00e1ra. Existuj\u00fa v\u0161ak aj mut\u00e1cie, ktor\u00e9 nieko\u013ekon\u00e1sobne zvy\u0161uj\u00fa riziko vzniku kolorekt\u00e1lneho karcin\u00f3mu a dedia sa v rodin\u00e1ch. <\/p>\n\n\n\n

A\u017e o 90 % vy\u0161\u0161ie riziko, ke\u010f pacienti nepodst\u00fapia lie\u010dbu<\/h2>\n\n\n\n

Jednou z tak\u00fdchto deden\u00fdch foriem je MUTYH asociovan\u00e1 polyp\u00f3za (MAP), pri ktorej doch\u00e1dza k zv\u00fd\u0161enej tvorbe polypov v hrubom \u010dreve. Tieto abnorm\u00e1lne v\u00fdrastky s\u00fa z po\u010diatku ne\u0161kodn\u00e9, av\u0161ak niektor\u00e9 polypy sa m\u00f4\u017eu \u010dasom zmeni\u0165 na zhubn\u00e9, \u010d\u00edm doch\u00e1dza k vzniku n\u00e1doru.<\/p>\n\n\n\n

Po 60-tke st\u00fapa riziko vzniku kolorekt\u00e1lneho karcin\u00f3mu u \u013eud\u00ed s MAP a\u017e o 43 – 63 %. Pre porovnanie, be\u017en\u00e1 popul\u00e1cia m\u00e1 riziko 5,5 %. Diagn\u00f3za MAP z\u00e1rove\u0148 vedie k zv\u00fd\u0161en\u00e9mu riziku rakoviny vaje\u010dn\u00edkov, mo\u010dov\u00e9ho mech\u00fara, dvan\u00e1stnika a \u0161t\u00edtnej \u017e\u013eazy. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Ako sa ded\u00ed MAP? <\/h2>\n\n\n\n

MAP sa ded\u00ed autozom\u00e1lne reces\u00edvnym sp\u00f4sobom. To znamen\u00e1, \u017ee na to, aby sa ochorenie prejavilo, je potrebn\u00e9 zdedi\u0165 od obidvoch rodi\u010dov po\u0161koden\u00fa k\u00f3piu ur\u010dit\u00e9ho g\u00e9nu.  V\u00fdnimo\u010dne m\u00f4\u017eu tieto mut\u00e1cie vznika\u0165 aj nanovo, po\u010das \u017eivota. V pr\u00edpade MAP je t\u00fdmto g\u00e9nom MUTYH. Tento g\u00e9n sa podie\u013ea na oprave po\u0161koden\u00ed DNA, ktor\u00e9 vznikli \u010dinnos\u0165ou vo\u013en\u00fdch radik\u00e1lov. Ak je dan\u00fd g\u00e9n nefunk\u010dn\u00fd a po\u0161kodenia na DNA nie s\u00fa opraven\u00e9, doch\u00e1dza ku vzniku mut\u00e1ci\u00ed.<\/p>\n\n\n\n

Jeden a\u017e dvaja \u013eudia zo sto<\/h2>\n\n\n\n

\u0160tatistiky uk\u00e1zali, \u017ee 1 a\u017e 2 zo 100 \u013eud\u00ed nes\u00fa vo svojej DNA jednu po\u0161koden\u00fa k\u00f3piu g\u00e9nu MUTYH. V takomto pr\u00edpade s\u00fa iba pren\u00e1\u0161a\u010dmi ochorenia, pri\u010dom \u0161t\u00fadie uk\u00e1zali, \u017ee ich riziko rozvoja kolorekt\u00e1lneho karcin\u00f3mu nie je vy\u0161\u0161ie ako u \u013eud\u00ed, ktor\u00ed maj\u00fa dve \u0161tandardn\u00e9 k\u00f3pie g\u00e9nu MUTYH. <\/p>\n\n\n\n

Poznanie poskytuje jedine\u010dn\u00fa formu prevencie<\/h2>\n\n\n\n

Inform\u00e1cia, \u017ee ste pren\u00e1\u0161a\u010dom je d\u00f4le\u017eit\u00e1 pre v\u0161etk\u00fdch rodi\u010dov. V pr\u00edpade, \u017ee toto ochorenie pren\u00e1\u0161aj\u00fa obidvaja rodi\u010dia, existuje 25 % \u0161anca, \u017ee ich die\u0165a zded\u00ed od oboch pr\u00e1ve po\u0161koden\u00fa k\u00f3piu g\u00e9nu. V pr\u00edpade, \u017ee ste pren\u00e1\u0161a\u010dom MAP, odpor\u00fa\u010dame v\u00e1m otestova\u0165 aj partnera alebo partnerku. Ak pren\u00e1\u0161ate ochorenie obaja, v \u010fal\u0161om kroku je vhodn\u00e9 otestova\u0165 deti. Poznanie tejto inform\u00e1cie im poskytuje jedine\u010dn\u00fa formu prevencie, ktor\u00e1 dok\u00e1\u017ee identifikova\u0165 mo\u017en\u00fd probl\u00e9m sk\u00f4r ako ak\u00e9ko\u013evek be\u017en\u00e9 prevent\u00edvne vy\u0161etrenie.<\/strong> <\/p>\n\n\n\n

Nov\u00e1 predispoz\u00edcia u\u017e vo va\u0161ej anal\u00fdze<\/h2>\n\n\n\n

Prihl\u00e1ste sa do svojho \u00fa\u010dtu<\/strong><\/a> vo webovej aplik\u00e1cii a pozrite si svoj v\u00fdsledok. Nov\u00e1 predispoz\u00edcia automaticky zdarma pribudla v\u0161etk\u00fdm na\u0161im s\u00fa\u010dasn\u00fdm z\u00e1kazn\u00edkom. Bud\u00faci z\u00e1kazn\u00edci n\u00e1jdu t\u00fato predispoz\u00edciu v DNA Complex teste<\/a> a DNA Health teste<\/a>. Pozna\u0165 svoje g\u00e9ny m\u00e1 zmysel v ka\u017edom veku. \u010c\u00edm sk\u00f4r, t\u00fdm lep\u0161ie. Za\u010dnite objavova\u0165 svoju DNA aj vy. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Zdroje:<\/strong><\/p>\n\n\n\n

    \n
  1. Curia MC, Catalano T, Aceto GM. MUTYH: Not just polyposis. World J Clin Oncol. 2020.<\/li>\n\n\n\n
  2. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK107219\/<\/a><\/li>\n\n\n\n
  3. https:\/\/my.clevelandclinic.org\/health\/diseases\/17254-myh-associated-polyposis<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Na\u0161i z\u00e1kazn\u00edci si vo svojich v\u00fdsledkoch n\u00e1jdu nov\u00fa predispoz\u00edciu spojen\u00fa s genetick\u00fdm ochoren\u00edm zaraden\u00fdm v kateg\u00f3rii Status pren\u00e1\u0161a\u010da. MUTYH asociovan\u00e1 polyp\u00f3za, v skratke MAP, je geneticky podmienen\u00e9 ochorenie prejavuj\u00face sa a\u017e v dospelosti. Z v\u00fdsledku anal\u00fdzy DNA m\u00f4\u017eete zisti\u0165 \u010di ste pren\u00e1\u0161a\u010dom ochorenia, ale aj \u010di m\u00e1te vy\u0161\u0161ie riziko vy sami. A pr\u00e1ve preto je […]<\/p>\n","protected":false},"author":6,"featured_media":1374791,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[58,59],"place-taxonomy":[],"class_list":["post-1374788","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sk","tag-dna-analyza","tag-dna-test"],"acf":[],"views":675,"yoast_head":"\nAj vznik polypov ved\u00facich k n\u00e1dorom ovplyv\u0148uj\u00fa g\u00e9ny - DNA ERA HU<\/title>\n<meta name=\"description\" content=\"MUTYH asociovan\u00e1 polyp\u00f3za, v skratke MAP, je geneticky podmienen\u00e9 ochorenie prejavuj\u00face sa a\u017e v dospelosti. 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