{"id":1383649,"date":"2026-01-14T08:50:12","date_gmt":"2026-01-14T07:50:12","guid":{"rendered":"https:\/\/dnaera.com\/cs\/?p=1383649"},"modified":"2026-02-18T08:12:29","modified_gmt":"2026-02-18T07:12:29","slug":"loeys-dietzuv-syndrom","status":"publish","type":"post","link":"https:\/\/dnaera.com\/cs\/blog\/loeys-dietzuv-syndrom\/","title":{"rendered":"Loeys-Dietz\u016fv syndrom: Tich\u00e1 hrozba ukryt\u00e1 v pojivov\u00e9 tk\u00e1ni."},"content":{"rendered":"\n<p><em>Ned\u00e1vno jsme se v\u011bnovali Marfanovu syndromu, jednomu z nejzn\u00e1m\u011bj\u0161\u00edch genetick\u00fdch onemocn\u011bn\u00ed postihuj\u00edc\u00edch pojivovou tk\u00e1\u0148. Jeliko\u017e mezi poruchami pojivov\u00e9 tk\u00e1n\u011b existuje v\u00edce p\u0159\u00edbuzn\u00fdch, ale z\u00e1rove\u0148 v\u00fdrazn\u011b odli\u0161n\u00fdch diagn\u00f3z, p\u0159irozen\u011b na toto t\u00e9ma navazujeme dal\u0161\u00edm onemocn\u011bn\u00edm z t\u00e9to skupiny \u2013 <strong>Loeys-Dietzov\u00fdm syndromem<\/strong>.<\/em><\/p>\n\n\n\n<p>Toto onemocn\u011bn\u00ed vznik\u00e1 v d\u016fsledku poruchy gen\u016f<strong> TGFBR1<\/strong> a <strong>TGFBR2<\/strong>, kter\u00e9 \u0159\u00edd\u00ed d\u016fle\u017eit\u00e9 procesy pot\u0159ebn\u00e9 pro pevnost a spr\u00e1vnou funkci pojivov\u00e9 tk\u00e1n\u011b. Pokud jsou tyto geny zm\u011bn\u011bn\u00e9, c\u00e9vy \u010di jin\u00e9 struktury t\u011bla jsou m\u00e9n\u011b odoln\u00e9, co\u017e m\u016f\u017ee v\u00e9st k roz\u0161i\u0159ov\u00e1n\u00ed tepen, tvorb\u011b aneuryzmat a dal\u0161\u00edm v\u00e1\u017en\u00fdm komplikac\u00edm. Navzdory tomu, \u017ee jde o vz\u00e1cn\u00e9 onemocn\u011bn\u00ed, jeho v\u010dasn\u00e9 zachycen\u00ed m\u016f\u017ee z\u00e1sadn\u011b ovlivnit kvalitu a d\u00e9lku \u017eivota.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Genetick\u00e9 pozad\u00ed<\/h2>\n\n\n\n<p>Z hlediska genetiky se Loeys-Dietz\u016fv syndrom d\u011bd\u00ed <strong>autozom\u00e1ln\u011b dominantn\u00edm zp\u016fsobem<\/strong>. Znamen\u00e1 to, \u017ee pokud jeden z rodi\u010d\u016f trp\u00ed t\u00edmto onemocn\u011bn\u00edm, existuje 50% pravd\u011bpodobnost, \u017ee j\u00edm bude posti\u017een\u00e9 i jeho d\u00edt\u011b. Z\u00e1rove\u0148 je d\u016fle\u017eit\u00e9 zd\u016fraznit, \u017ee p\u0159ibli\u017en\u011b 75 % p\u0159\u00edpad\u016f Loeys-Dietzova syndromu vznik\u00e1 jako <strong>spont\u00e1nn\u00ed mutace <\/strong>je\u0161t\u011b p\u0159ed po\u010det\u00edm ve spermi\u00edch nebo vaj\u00ed\u010dk\u00e1ch, a tedy m\u016f\u017ee postihnout i d\u00edt\u011b zdrav\u00fdch rodi\u010d\u016f.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>Klinick\u00e9 projevy<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>Projevy Loeys-Dietzova syndromu jsou r\u016fznorod\u00e9 a mohou se objevit v d\u011btstv\u00ed nebo a\u017e v dosp\u011blosti. Nejz\u00e1va\u017en\u011bj\u0161\u00ed jsou<strong> c\u00e9vn\u00ed komplikace<\/strong>, jeliko\u017e oslaben\u00e9 tepny se mohou nebezpe\u010dn\u011b roz\u0161i\u0159ovat a snadn\u011bji po\u0161kodit. Krom\u011b aorty mohou b\u00fdt posti\u017een\u00e9 i men\u0161\u00ed c\u00e9vy a nen\u00ed neobvykl\u00e9, \u017ee maj\u00ed nep\u0159irozen\u011b klikat\u00fd pr\u016fb\u011bh. Posti\u017een\u00fd m\u016f\u017ee m\u00edt tak\u00e9 skoli\u00f3zu, deformity hrudn\u00edku, dlouh\u00e9 prsty \u010di zv\u00fd\u0161enou pohyblivost kloub\u016f. Tenk\u00e1 k\u016f\u017ee, v\u00fdrazn\u00e9 jizvy a snadn\u00e1 tvorba mod\u0159in pat\u0159\u00ed mezi typick\u00e9 ko\u017en\u00ed projevy. Kraniofaci\u00e1ln\u00ed znaky mohou zahrnovat v\u011bt\u0161\u00ed vzd\u00e1lenost mezi o\u010dima \u010di roz\u0161t\u011bpenou uvulu. \u010cast\u00e9 jsou tak\u00e9 projevy na imunit\u011b, jako alergie, ekz\u00e9my, astma nebo z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed tr\u00e1vic\u00edho traktu. Zrak b\u00fdv\u00e1 posti\u017een kr\u00e1tkozrakost\u00ed nebo \u0161ilh\u00e1n\u00edm.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>Pro\u010d je dobr\u00e9 zn\u00e1t tuto predispozici<\/strong>?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>Vzhledem k tomu, \u017ee Loeys-Dietz\u016fv syndrom je v\u00fdlu\u010dn\u011b geneticky podm\u00edn\u011bn\u00e9 onemocn\u011bn\u00ed, strava ani \u017eivotn\u00ed styl nemaj\u00ed vliv na rozvoj tohoto onemocn\u011bn\u00ed. Z tohoto d\u016fvodu m\u016f\u017ee b\u00fdt pozn\u00e1n\u00ed predispozice pro rozvoj tohoto onemocn\u011bn\u00ed kl\u00ed\u010dov\u00e9 pro p\u0159edch\u00e1zen\u00ed v\u00e1\u017en\u00fdm komplikac\u00edm. L\u00e9ka\u0159i mohou pacient\u016fm doporu\u010dit vyhnout se fyzick\u00fdm aktivit\u00e1m, kter\u00e9 by mohly zv\u00fd\u0161it riziko po\u0161kozen\u00ed c\u00e9v a kloub\u016f. V\u010dasn\u00e1 informovanost umo\u017e\u0148uje p\u0159izp\u016fsobit \u017eivotn\u00ed styl a zah\u00e1jit specializovanou l\u00e9\u010dbu, kter\u00e1 pom\u00e1h\u00e1 minimalizovat zdravotn\u00ed rizika a p\u0159edch\u00e1zet dlouhodob\u00fdm d\u016fsledk\u016fm spojen\u00fdm s t\u00edmto onemocn\u011bn\u00edm.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Nov\u00fd v\u00fdsledek anal\u00fdzy<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p><a href=\"https:\/\/app.dnaera.com\/sign-in?&amp;lng=cz\">P\u0159ihlaste se<\/a> do sv\u00fdch v\u00fdsledk\u016f. Genetick\u00e1 predispozice pro rozvoj Loeys-Dietzova syndromu je odte\u010f zdarma dostupn\u00e1 pro v\u0161echny na\u0161e z\u00e1kazn\u00edky. Z\u00e1rove\u0148 ji bude m\u00edt ve sv\u00e9 anal\u00fdze ka\u017ed\u00fd budouc\u00ed z\u00e1kazn\u00edk, kter\u00fd vstoup\u00ed do sv\u011bta DNA s <a href=\"https:\/\/dnaera.com\/cs\/produkt\/dna-complex-test\/\" target=\"_blank\" rel=\"noreferrer noopener\">DNA Complex testem<\/a>. Poznejte sv\u00e9 predispozice i vy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><strong>Zdroje<\/strong><\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li class=\"has-small-font-size\">Loeys, B. L. Loeys-Dietz Syndrome Synonym: Loeys-Dietz Aortic Aneurysm Syndrome.<\/li>\n\n\n\n<li>Gouda, P., Kay, R., Habib, M., Aziz, A., Aziza, E., &amp; Welsh, R. (2022). Clinical features and complications of Loeys-Dietz syndrome: a systematic review. International Journal of Cardiology, 362, 158-167.<\/li>\n\n\n\n<li><a href=\"https:\/\/www.healthline.com\/health\/loeys-dietz-syndrome#causes\">https:\/\/www.healthline.com\/health\/loeys-dietz-syndrome#causes<\/a><\/li>\n\n\n\n<li class=\"has-small-font-size\"><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/23237-loeys-dietz-syndrome\">https:\/\/my.clevelandclinic.org\/health\/diseases\/23237-loeys-dietz-syndrome<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ned\u00e1vno jsme se v\u011bnovali Marfanovu syndromu, jednomu z nejzn\u00e1m\u011bj\u0161\u00edch genetick\u00fdch onemocn\u011bn\u00ed postihuj\u00edc\u00edch pojivovou tk\u00e1\u0148. Jeliko\u017e mezi poruchami pojivov\u00e9 tk\u00e1n\u011b existuje v\u00edce p\u0159\u00edbuzn\u00fdch, ale z\u00e1rove\u0148 v\u00fdrazn\u011b odli\u0161n\u00fdch diagn\u00f3z, p\u0159irozen\u011b na toto t\u00e9ma navazujeme dal\u0161\u00edm onemocn\u011bn\u00edm z t\u00e9to skupiny \u2013 Loeys-Dietzov\u00fdm syndromem. Toto onemocn\u011bn\u00ed vznik\u00e1 v d\u016fsledku poruchy gen\u016f TGFBR1 a TGFBR2, kter\u00e9 \u0159\u00edd\u00ed d\u016fle\u017eit\u00e9 procesy pot\u0159ebn\u00e9 [&hellip;]<\/p>\n","protected":false},"author":876,"featured_media":1383650,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":"[]"},"categories":[33],"tags":[58,59,100],"place-taxonomy":[],"class_list":["post-1383649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-cs","tag-dna-analyza","tag-dna-test","tag-predispozice"],"acf":[],"views":2675,"_links":{"self":[{"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1383649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/users\/876"}],"replies":[{"embeddable":true,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/comments?post=1383649"}],"version-history":[{"count":1,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1383649\/revisions"}],"predecessor-version":[{"id":1383651,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1383649\/revisions\/1383651"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/media\/1383650"}],"wp:attachment":[{"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/media?parent=1383649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/categories?post=1383649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/tags?post=1383649"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dnaera.com\/cs\/wp-json\/wp\/v2\/place-taxonomy?post=1383649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}